Sophie Cohen (also called "The Nana") is the mother of Sandy and his younger siblings, whose names are unknown. Sophie is also the paternal grandmother of Seth and Sophie Rose, and the adoptive one of Ryan Atwood. Besides being Kirsten's mother-in-law.
During a Passover Seder visit, the family's negative views about her change as she informs them that she has been diagnosed with lung cancer. She does not want chemotherapy, but the family persuades her to seek treatment. She then leaves in New York.
She living in southern Florida and presenting a new fiancé during a visit from Sandy, Seth and Ryan. Ever protective of his mother's well-being, Sandy is suspicious of the background of Sophie's new love, eventually discovering a foundation for his mistrust. He drives away the suitor, who apparently sought to profit from Sophie's retirement savings. Though Sophie is not quick to agree with her son's actions or his rationale for them, the two eventually reconcile before the end of the visit.